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Leprosy, also known as Hansen's disease, is an infectious disease caused by the Mycobacterium leprae bacterium that can lead to disfiguration of the body or skin. The modern term for the disease is named after the discoverer of the bacterium, Gerhard Armauer Hansen.
Contents
[hide]
* 1 Treatment
* 2 Clinical features
* 3 Transmission
* 4 Incidence
* 5 Risk groups
* 6 Term "Leprosy"
* 7 Asylums
* 8 Famous people with leprosy
* 9 See also
* 10 In literature and film
* 11 References
* 12 Further reading
* 13 External links
[edit]
Treatment
Historically, leprosy was an incurable and disfiguring disease. It is traditionally believed that lepers were shunned and sequestered in leper colonies. However, this is an oversimplistic explanation not at all supported by historical evidence. A very great number of leprosaria or leper hospitals sprang up in the middle ages, particularly in England, and there were 250 in England around 1230 A.D., the first recorded one being at Harbledown. These institutions were run along monastic lines, and whilst lepers were encouraged to live in these monastic type establishments, this was for the health of their own souls as well a segregation policy. Indeed, in Catholic tradition, those suffering from leprosy were considered to be going through Purgatory on Earth, and for this reason their suffering was considered more holy than the ordinary person's. Saint Radegund was noted for washing the feet of lepers, and Orderic Vitalis writes of a monk, Ralf, who was so overcome by the plight of the leper that he prayed to catch leprosy himself (he eventually did catch it). The leper would carry a clapper and bell to warn of his approach, and this was as much to attract attention for charity as to warn people that a diseased person was near. Most importantly, Jesus was said to have walked with the leper, and so in medieval religious society, it was a noble thing to be able to converse and build relationships with the leper.
Dapsone was used to treat leprosy from 1946, but it was necessary to take dapsone for months if not years, making compliance difficult. Search for more effective medicines led to the discovery of clofazimine and rifampin in the sixties at Novartis. Of the two, rifampin proved to be particularly effective. The first study using rifampin to treat leprosy was published in 1970.[1] A major breakthrough occurred in leprosy treatment in 1982, with the introduction of Multi-Drug-Therapy (MDT) based on studies published by Shantaram Yawalkar and colleagues.[2] The treatment Yawalkar formulated consisted of dapsone and rifampin combination.
For most people, a six month course of tablets for the milder form of leprosy and two years for the more severe form will cure them of the disease. However, for those who suffer a disabling reaction caused by the build-up of dead bacilli in the body, additional steroid treatment is given.
The main challenges in the eradication of Hansen's disease are in reaching populations that have not yet received multidrug therapy services, improving detection of the disease, providing patients with high-quality services and affordable drugs, and fighting social taboos about the disease where patients are considered to be "unclean", or "cursed by God" as outcasts. The last issue is important to address, because in such societies, patients may be forced to hide their condition (and thus not to seek treatment) in order not to be discriminated against, since the lack of awareness about Hansen's disease leads people to falsely believe that the disease is highly contagious and incurable. Since 1995, the World Health Organization (WHO) has provided all endemic countries with free MDT, supplied through Ministries of Health. In December 2005, an agreement was signed between the WHO and the pharmaceutical company Novartis to extend this free provision until at least the end of 2010.
[edit]
Clinical features
The disease affects the skin, nerves, and mucous membranes. This chronic infectious disease usually affects the skin and peripheral nerves but has a wide range of possible clinical manifestations. Patients are classified as having paucibacillary (tuberculoid leprosy) or multibacillary Hansen's disease (lepromatous leprosy). Paucibacillary Hansen's disease is milder and characterized by one or more hypopigmented skin macules. Multibacillary Hansen's disease is associated with symmetric skin lesions, nodules, plaques, thickened dermis, and frequent involvement of the nasal mucosa resulting in nasal congestion and epistaxis (nose bleeds). Contrary to popular belief, Hansen's bacillus does not cause rotting of the flesh; however, due to the body's extensive attempts to rid itself of the bacterium, defenses such as inflammation, cytokines, activated macrophages and other mechanisms cause tissue destruction and regeneration leading to excessive growth and eventually mutilation.
[edit]
Transmission
The mode of transmission of Hansen's disease remains uncertain. Most investigators believe that the bacterium is spread from person to person through respiratory droplets. What is known is that the transmission rate is very low. In addition, approximately 95% of people who are exposed to it do not develop leprosy.[3]
[edit]
Incidence
Aside from humans, other creatures that are known to be susceptible to leprosy are the armadillo, mangabey monkeys, rabbits, and mice (on their footpads).
According to recent figures from the World Health Organization (WHO) new cases detected worldwide have decreased by approximately 107,000 cases or 21% from 2003 to 2004. This decreasing trend has been consistent for the past three years. In addition the "global registered prevalence" of leprosy was 286,063 cases with 407,791 new cases being detected during 2004.
In 1999, the world incidence of Hansen's disease was estimated to be 640,000; and in 2000, 738,284 cases were identified. In 1999, 108 cases occurred in the United States. In 2000, the World Health Organization (WHO) listed 91 countries in which Hansen's disease is endemic, with India, Myanmar, and Nepal having 70% of cases. In 2002, 763,917 new cases were detected worldwide, and in that year the WHO listed Brazil, Madagascar, Mozambique, Tanzania and Nepal as having 90% of Hansen's disease cases.
Worldwide, one to two million people are permanently disabled because of Hansen's disease. However, persons receiving antibiotic treatment or having completed treatment are considered free of active infection. India has the greatest number of leprosy cases, with Brazil second and Myanmar third.
Hansen's disease is one of the infectious diseases tracked passively by the Centers for Disease Control and Prevention. Its prevalence in the United States has remained low and relatively stable. There are decreasing numbers of cases worldwide, though pockets of high prevalence continue in certain areas such as Brazil, South Asia (India, Nepal), some parts of Africa (Tanzania, Madagascar, Mozambique) and the western Pacific.
[edit]
Risk groups
Those having close contacts with patients with untreated, active, predominantly multibacillary disease, and persons living in countries with highly endemic disease are at risk of contracting the disease. Recent research suggests that there is genetic variation in susceptibility. The region of DNA responsible for this variability is also involved in Parkinson's disease, giving rise to current speculation that the two disorders may be linked in some way at the biochemical level. In addition, men are two times more likely to contract leprosy than women.
[edit]
Term "Leprosy"
Sufferers of Hansen's disease have historically been known as lepers, however this term is falling into disuse as a result of the diminishing number of leprosy patients and the pejorative connotations of the term. In fact, the term that is now most widely accepted among people and agencies working in the field of leprosy is "people affected by leprosy". The terms "leprosy" and "lepers" can also lead to public misunderstanding because the Bible uses these terms in reference to a wide range of skin conditions other than Hansen's disease. The term itself first appeared in the English language in the 1300's coming from Greek and Hebrew. [4]
[edit]
Asylums
There are still a few leper colonies around the world, in countries such as India and the Philippines.
Western humanitarian and church organizations regularly send relief supplies, including handmade "leper bandages"; bandages knitted or crocheted out of cotton, for greater breathability and durability than traditional gauze. The bandages can also be washed, sterilized, and reused making them more cost effective as well. Though leper bandages can be machine made, the colony inhabitants tend to appreciate the handmade variety.
In 2001, government-run leper colonies in Japan came under judicial scrutiny, leading to the determination that the Japanese government had mistreated the patients, and the District Court ordered Japan to pay compensation to former patients [1]. In 2002, a formal inquiry into these colonies was set up, and in March of 2005, the policy was strongly denounced. "Japan's policy of absolute quarantine... did not have any scientific grounds." [2] The inquiry denounced not only the government and the doctors which are involved with the policy but also the court which repeatedly ruled in the favour of the government when the policy was challenged, as well as the media which fail to report the plight of the victims. There are about 7000 records of forced abortion and sterlisation. In some instance of late term "abortion", it is reported that babies are suffocated and killed after birth. [3]
[edit]
| Neglected diseases
Contents
[hide]
* 1 Treatment
* 2 Clinical features
* 3 Transmission
* 4 Incidence
* 5 Risk groups
* 6 Term "Leprosy"
* 7 Asylums
* 8 Famous people with leprosy
* 9 See also
* 10 In literature and film
* 11 References
* 12 Further reading
* 13 External links
[edit]
Treatment
Historically, leprosy was an incurable and disfiguring disease. It is traditionally believed that lepers were shunned and sequestered in leper colonies. However, this is an oversimplistic explanation not at all supported by historical evidence. A very great number of leprosaria or leper hospitals sprang up in the middle ages, particularly in England, and there were 250 in England around 1230 A.D., the first recorded one being at Harbledown. These institutions were run along monastic lines, and whilst lepers were encouraged to live in these monastic type establishments, this was for the health of their own souls as well a segregation policy. Indeed, in Catholic tradition, those suffering from leprosy were considered to be going through Purgatory on Earth, and for this reason their suffering was considered more holy than the ordinary person's. Saint Radegund was noted for washing the feet of lepers, and Orderic Vitalis writes of a monk, Ralf, who was so overcome by the plight of the leper that he prayed to catch leprosy himself (he eventually did catch it). The leper would carry a clapper and bell to warn of his approach, and this was as much to attract attention for charity as to warn people that a diseased person was near. Most importantly, Jesus was said to have walked with the leper, and so in medieval religious society, it was a noble thing to be able to converse and build relationships with the leper.
Dapsone was used to treat leprosy from 1946, but it was necessary to take dapsone for months if not years, making compliance difficult. Search for more effective medicines led to the discovery of clofazimine and rifampin in the sixties at Novartis. Of the two, rifampin proved to be particularly effective. The first study using rifampin to treat leprosy was published in 1970.[1] A major breakthrough occurred in leprosy treatment in 1982, with the introduction of Multi-Drug-Therapy (MDT) based on studies published by Shantaram Yawalkar and colleagues.[2] The treatment Yawalkar formulated consisted of dapsone and rifampin combination.
For most people, a six month course of tablets for the milder form of leprosy and two years for the more severe form will cure them of the disease. However, for those who suffer a disabling reaction caused by the build-up of dead bacilli in the body, additional steroid treatment is given.
The main challenges in the eradication of Hansen's disease are in reaching populations that have not yet received multidrug therapy services, improving detection of the disease, providing patients with high-quality services and affordable drugs, and fighting social taboos about the disease where patients are considered to be "unclean", or "cursed by God" as outcasts. The last issue is important to address, because in such societies, patients may be forced to hide their condition (and thus not to seek treatment) in order not to be discriminated against, since the lack of awareness about Hansen's disease leads people to falsely believe that the disease is highly contagious and incurable. Since 1995, the World Health Organization (WHO) has provided all endemic countries with free MDT, supplied through Ministries of Health. In December 2005, an agreement was signed between the WHO and the pharmaceutical company Novartis to extend this free provision until at least the end of 2010.
[edit]
Clinical features
The disease affects the skin, nerves, and mucous membranes. This chronic infectious disease usually affects the skin and peripheral nerves but has a wide range of possible clinical manifestations. Patients are classified as having paucibacillary (tuberculoid leprosy) or multibacillary Hansen's disease (lepromatous leprosy). Paucibacillary Hansen's disease is milder and characterized by one or more hypopigmented skin macules. Multibacillary Hansen's disease is associated with symmetric skin lesions, nodules, plaques, thickened dermis, and frequent involvement of the nasal mucosa resulting in nasal congestion and epistaxis (nose bleeds). Contrary to popular belief, Hansen's bacillus does not cause rotting of the flesh; however, due to the body's extensive attempts to rid itself of the bacterium, defenses such as inflammation, cytokines, activated macrophages and other mechanisms cause tissue destruction and regeneration leading to excessive growth and eventually mutilation.
[edit]
Transmission
The mode of transmission of Hansen's disease remains uncertain. Most investigators believe that the bacterium is spread from person to person through respiratory droplets. What is known is that the transmission rate is very low. In addition, approximately 95% of people who are exposed to it do not develop leprosy.[3]
[edit]
Incidence
Aside from humans, other creatures that are known to be susceptible to leprosy are the armadillo, mangabey monkeys, rabbits, and mice (on their footpads).
According to recent figures from the World Health Organization (WHO) new cases detected worldwide have decreased by approximately 107,000 cases or 21% from 2003 to 2004. This decreasing trend has been consistent for the past three years. In addition the "global registered prevalence" of leprosy was 286,063 cases with 407,791 new cases being detected during 2004.
In 1999, the world incidence of Hansen's disease was estimated to be 640,000; and in 2000, 738,284 cases were identified. In 1999, 108 cases occurred in the United States. In 2000, the World Health Organization (WHO) listed 91 countries in which Hansen's disease is endemic, with India, Myanmar, and Nepal having 70% of cases. In 2002, 763,917 new cases were detected worldwide, and in that year the WHO listed Brazil, Madagascar, Mozambique, Tanzania and Nepal as having 90% of Hansen's disease cases.
Worldwide, one to two million people are permanently disabled because of Hansen's disease. However, persons receiving antibiotic treatment or having completed treatment are considered free of active infection. India has the greatest number of leprosy cases, with Brazil second and Myanmar third.
Hansen's disease is one of the infectious diseases tracked passively by the Centers for Disease Control and Prevention. Its prevalence in the United States has remained low and relatively stable. There are decreasing numbers of cases worldwide, though pockets of high prevalence continue in certain areas such as Brazil, South Asia (India, Nepal), some parts of Africa (Tanzania, Madagascar, Mozambique) and the western Pacific.
[edit]
Risk groups
Those having close contacts with patients with untreated, active, predominantly multibacillary disease, and persons living in countries with highly endemic disease are at risk of contracting the disease. Recent research suggests that there is genetic variation in susceptibility. The region of DNA responsible for this variability is also involved in Parkinson's disease, giving rise to current speculation that the two disorders may be linked in some way at the biochemical level. In addition, men are two times more likely to contract leprosy than women.
[edit]
Term "Leprosy"
Sufferers of Hansen's disease have historically been known as lepers, however this term is falling into disuse as a result of the diminishing number of leprosy patients and the pejorative connotations of the term. In fact, the term that is now most widely accepted among people and agencies working in the field of leprosy is "people affected by leprosy". The terms "leprosy" and "lepers" can also lead to public misunderstanding because the Bible uses these terms in reference to a wide range of skin conditions other than Hansen's disease. The term itself first appeared in the English language in the 1300's coming from Greek and Hebrew. [4]
[edit]
Asylums
There are still a few leper colonies around the world, in countries such as India and the Philippines.
Western humanitarian and church organizations regularly send relief supplies, including handmade "leper bandages"; bandages knitted or crocheted out of cotton, for greater breathability and durability than traditional gauze. The bandages can also be washed, sterilized, and reused making them more cost effective as well. Though leper bandages can be machine made, the colony inhabitants tend to appreciate the handmade variety.
In 2001, government-run leper colonies in Japan came under judicial scrutiny, leading to the determination that the Japanese government had mistreated the patients, and the District Court ordered Japan to pay compensation to former patients [1]. In 2002, a formal inquiry into these colonies was set up, and in March of 2005, the policy was strongly denounced. "Japan's policy of absolute quarantine... did not have any scientific grounds." [2] The inquiry denounced not only the government and the doctors which are involved with the policy but also the court which repeatedly ruled in the favour of the government when the policy was challenged, as well as the media which fail to report the plight of the victims. There are about 7000 records of forced abortion and sterlisation. In some instance of late term "abortion", it is reported that babies are suffocated and killed after birth. [3]
[edit]
| Neglected diseases
posted by Che Elias at 11:53 AM
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Beck Hansen disease known as laptoprosy...
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